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Fasudil, 98+%, Thermo Scientific™ Product Code.: 15415739
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Fasudil, 98+%, Thermo Scientific™

Product Code. 15415739
10mg
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Quantity:
10mg
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Product Code. 15415739

Brand: Thermo Scientific Alfa Aesar J63525.MA

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Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Applications
HA-1077 dihydrochloride has been shown to be a vasodilating agent as well as a potent inhibitor of Rock-2 (Rho-associated Kinase II), cGKI (cGMP-dependent protein kinase), PKA (cAMP-dependent protein kinase), MYLK, and CaMKII. Rho kinase signaling pathways are thought to cause invasion, migration, and proliferation of certain cells. Studies have shown this compound can also inhibit myosin light chain kinase in vitro and suppress cell rounding by myosin light chain phosphorylation. Mechanistic experiments report that HA-1077 inhibits vascular smooth muscle contraction by acting as a calcium channel protein inhibitor. HA-1077 dihydrochloride is an inhibitor of MSK1, PKC, PRK2 and Rsk-2.

Solubility
Soluble in water or DMSO

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.
TRUSTED_SUSTAINABILITY

Specifications

CAS 103745-39-7
Molecular Formula C14H17N3O2S
MDL Number MFCD00866182
Quantity 10mg
Merck Index 14,3942
Synonym fasudil, fasudil inn, 5-1,4-diazepane-1-sulfonyl isoquinoline, fasudilum inn-latin, 1-5-isoquinolinesulfonyl homopiperazine, unii-q0ch43pgxs, 1h-1,4-diazepine, hexahydro-1-5-isoquinolinylsulfonyl, 5-1,4-diazepan-1-ylsulfonyl isoquinoline, 5-isoquinolinesulfonyl homopiperazine, q0ch43pgxs
Solubility Information Soluble in water or DMSO
InChI Key NGOGFTYYXHNFQH-UHFFFAOYSA-N
SMILES C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
IUPAC Name 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline
Molecular Weight (g/mol) 291.369
PubChem CID 3547
Formula Weight 327.83
Percent Purity ≥98%
Chemical Name or Material Fasudil
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5 results found
Lot Number Certificate Type Date Catalog Number
Lot NumberZ03K022 Certificate TypeCertificate of Analysis Date04/12/2024 Catalog NumberJ63525.MF,J63525.MA
Lot NumberZ11J028 Certificate TypeCertificate of Analysis Date08/01/2024 Catalog NumberJ63525.MF,J63525.MA
Lot NumberN19F068 Certificate TypeCertificate of Analysis Date08/12/2021 Catalog NumberJ63525.MF,J63525.MA
Lot NumberM21F003 Certificate TypeCertificate of Analysis Date06/12/2021 Catalog NumberJ63525.MF,J63525.MA
Lot NumberR01B037 Certificate TypeCertificate of Analysis Date06/12/2021 Catalog NumberJ63525.MF,J63525.MA

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