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Tocris Bioscience™ A 83-01
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Artikelnummer. 18084932
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50 mg
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18084932 10 mg
18025492 50 mg
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Artikelnummer. 18084932 Leverandør Tocris Bioscience™ Leverandørnr. 2939/10

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Beskrivelse

Selective inhibitor of TGF-βRI, ALK4 and ALK7

A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). A 83-01 blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than SB 431542 (Cat. No. 1614). A 83-01 inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs. Also promotes neural differentiation of hPSCs as part of a chemical cocktail.

For more information about how A 83-01 may be used, see our protocol: Converting Fibroblasts into Cardiomyocytes (9C Cocktail)

TRUSTED_SUSTAINABILITY

Kemiske identifikatorer

CAS 909910-43-6
Molekylær formel C25H19N5S

Tekniske data

Kemisk navn eller materiale A 83-01
Mængde 10 mg
Formel vægt 421.52
Renhed >98%
Molekylvægt (g/mol) 421.522
Produkttitel
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