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  6. AZD 2461, Tocris Bioscience™

AZD 2461, Tocris Bioscience™

Product Code. 30000929
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Quantity:
10 mg
50 mg
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Description

Potent PARP inhibitor; orally bioavailable

AZD 2461 is a potent PARP inhibitor (IC50 values are 2, 5 and 200 nM for PARP2, PARP1 and PARP3, respectively). Exhibits anticancer effects in BRCA1 mutant, but not wild-type breast cancer cell lines in vitro. Inhibits growth of olaparib -resistant mammary tumors in a mouse model and is a poor substrate for the P-gp transporter. Orally bioavailable.

Chemical Identifiers

CAS 1174043-16-3
Molecular Formula C22H22FN3O3
Molecular Weight (g/mol) 395.434
InChI Key HYNBNUYQTQIHJK-UHFFFAOYSA-N
Synonym AZD 2461
PubChem CID 44199317
IUPAC Name 4-[[4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one
SMILES COC1CCN(CC1)C(=O)C2=C(C=CC(=C2)CC3=NNC(=O)C4=CC=CC=C43)F

Specifications

Linear Formula C22H22FN3O3
Quantity 10 mg
Solubility Information Soluble to 100mM in DMSO and to 100mM in ethanol
Formula Weight 395.43
Physical Form Solid
Chemical Name or Material 4-[[4-Fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone
Grade >98%
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