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CD38 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA512509
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Description
This antibody is predicted to react with non-human primate based on sequence homology.
CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. CD38 participates in cell adhesion, signal transduction and calcium signaling. Further, CD38 is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma and neuroblastoma. Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome.
Specifications
| CD38 | |
| Polyclonal | |
| Unconjugated | |
| CD38 | |
| 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADPRC 1; ADPRC1; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; Cd38; CD38 antigen; CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase); CD38 antigen (p45); CD38 antigen p45; CD38 molecule; CD38H; Cd38-rs1; cluster of differentiation 38; cyclic ADP-ribose hydrolase 1; ecto-nicotinamide adenine dinucleotide glycohydrolase; I-19; NAD(+) nucleosidase; NAD+ nucleosidase; NIM-R5 antigen; T10 | |
| Rabbit | |
| Ammonium sulfate precipitation, Size-exclusion - Dialysis | |
| RUO | |
| 952 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
| 1.7 mg/mL | |
| PBS with 0.09% sodium azide | |
| P28907 | |
| CD38 | |
| KLH conjugated synthetic peptide between 241-270 amino acids from the C-terminal region of human CD38 | |
| 400 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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