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DL-TBOA, Tocris Bioscience™

Product Code. 30001210
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Quantity:
10 mg
50 mg
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Description

Selective non-transportable inhibitor of EAATs

DL-TBOA is a competitive, non-transportable blocker of excitatory amino acid transporters (IC50 values are 6 μM, 6 μM and 70 μM, for EAAT2, EAAT3 and EAAT1 respectively). DL-TBOA also inhibits EAAT4 and EAAT5 (Ki values are 4.4 μM and 3.2 μM respectively). DL-TBOA displays high selectivity for EAATs over ionotropic and metabotropic glutamate receptors. DL-TBOA augments SN 38 (Cat. No. 2684) induced colorectal cancer cell death in drug-resistant cell lines. DL-TBOA enhances synaptic activity in the frog labyrinth.

Chemical Identifiers

CAS 205309-81-5
Molecular Formula C11H13NO5
Molecular Weight (g/mol) 239.227
InChI Key BYOBCYXURWDEDS-IUCAKERBSA-N
Synonym dl-tboa, chembl79140, dl-threo-beta-benzyloxyaspartate, 3s-3-benzyloxy-l-aspartic acid, 2s,3s-2-amino-3-benzyloxy succinic acid, tboa, 2s,3s-2-amino-3-benzyloxy-succinic acid, tocris-1223, d07gub, l-threo-benzyloxy aspartate
PubChem CID 5311218
IUPAC Name (2S,3S)-2-amino-3-phenylmethoxybutanedioic acid
SMILES C1=CC=C(C=C1)COC(C(C(=O)O)N)C(=O)O

Specifications

Formula Weight 239.23
Percent Purity >98%
Quantity 10 mg
Chemical Name or Material DL-TBOA
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