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STEMCELL Technologies EC23
Retinoid pathway activator; Activates retinoic acid receptor (RAR)
Brand: STEMCELL Technologies 73102
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Description
- EC23 is a retinoic acid receptor (RAR) agonist with pan-RAR activity (EC50: RARα 41 nM, RARβ 0.5 nM, RARγ 0.4 nM), while having no appreciable activity for retinoid X receptors (RXR; EC50> 10μM for all; Gambone et al.) It is a photostable synthetic analog of all-trans retinoic acid (ATRA; Christie et al. 2008)
- EC23 also weakly activates aryl hydrocarbon receptor (Gambone et al.)
- Induces neural differentiation of human pluripotent stem cells, similarly to ATRA (Christie et al. 2010; Clemens et al.)
- Induces neuronal differentiation of human fetal neural progenitor cell line ReNcell 197VM (Christie et al. 2010)
Specifications
| 104561-41-3 | |
| 1 mg | |
| ≥98% |
| AGN 190205; BASF 46928 | |
| C23H24O2 |
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STEMCELL Technologies EC23
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