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Glybenzcyclamide, 99%, Thermo Scientific Chemicals Product Code.: 11456974
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Glybenzcyclamide, 99%, Thermo Scientific Chemicals

Product Code. 11456974
25 g
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Quantity:
25 g
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Product Code. 11456974

Brand: Thermo Scientific Alfa Aesar B21459.14

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Description

Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glyburide (Glibenclamide) is an ATP-dependent K+ channel (KIR6, KATP) and CFTR Cl- channel blocker. This compound inhibits recombinant CFTR Cl- channels (IC50 = 20 M).

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glyburide (Glibenclamide) is an ATP-dependent K+ channel (KIR6, KATP) and CFTR Cl- channel blocker. This compound inhibits recombinant CFTR Cl- channels (IC50 = 20 μM).

Solubility
Soluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (1:36), methanol (1:250), and DMF. Insoluble in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 10238-21-8
Molecular Formula C23H28ClN3O5S
Molecular Weight (g/mol) 494.003
MDL Number MFCD00056625
InChI Key ZNNLBTZKUZBEKO-UHFFFAOYSA-N
Synonym glyburide, glibenclamide, glybenclamide, micronase, diabeta, glynase, daonil, euglucon, maninil, semi-daonil
PubChem CID 3488
ChEBI CHEBI:5441
IUPAC Name 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
SMILES COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3

Specifications

Melting Point 171°C to 174°C
Quantity 25 g
Solubility Information Soluble in ethanol (5mg/mL),DMSO (25mg/mL),chloroform (1:36),methanol (1:250),and DMF. Insoluble in water.
Formula Weight 494.01
Percent Purity 99%
Chemical Name or Material Glybenzcyclamide

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5 results found
Lot Number Certificate Type Date Catalog Number
Lot NumberU22K014 Certificate TypeCertificate of Analysis Date11/09/2024 Catalog NumberB21459.22,B21459.14
Lot Number10244888 Certificate TypeCertificate of Analysis Date24/10/2023 Catalog NumberB21459.22,B21459.14
Lot NumberQ20J017 Certificate TypeCertificate of Analysis Date02/05/2023 Catalog NumberB21459.14
Lot Number10243170 Certificate TypeCertificate of Analysis Date31/08/2022 Catalog NumberB21459.22,B21459.14
Lot NumberQ18I033 Certificate TypeCertificate of Analysis Date26/04/2022 Catalog NumberB21459.22,B21459.14

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