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Gibco™ Human FGF-basic (FGF-2/bFGF) (aa 10-155) Recombinant Protein Product Code.: 10202733
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Gibco™ Human FGF-basic (FGF-2/bFGF) (aa 10-155) Recombinant Protein

Product Code. 10202733
100 μg, 100µg
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Quantity:
1 mg
10 μg
100 μg
50 μg
Unit Size:
100µg
50µg
Each
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Product Code. 10202733

Brand: Gibco™ PHG0021

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Description

Recombinant Protein

Carrier-Free Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile, distilled water to 0.1-0.5 mg/mL. Apportion the reconstituted protein into working aliquots and store at ≤-20°C. Make any further dilutions of the reconstituted protein in medium or buffered solution containing carrier protein, such as PBS with 0.1% BSA. Storage: Store the lyophilized protein at 2-8°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at ≤-20°C (not in a frost-free freezer). Avoid repeated freeze-thaw cycles.

FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P09038
For Use With (Application) Control, ELISA, Functional Assay, Immunohistochemistry, Western Blot
Formulation protein with no preservative
Gene ID (Entrez) 2247
Molecular Weight (g/mol) 17 kDa
Name Human FGF-basic (FGF-2/bFGF) (aa 10-155)
Purification Method Sequential Chromatography
Quantity 100 μg
Endotoxin Concentration <0.1 ng/ μg
Gene Alias Basic fibroblast growth factor; basic fibroblast growth factor bFGF; bFGF; FGF; fgf basic; Fgf2; Fgf-2; Fgfb; FGF-b; Fibroblast growth factor; fibroblast growth factor 2; fibroblast growth factor 2 (basic); HBGF-2; Heparin-binding growth factor 2; H-FGF-b-147; H-FGF-b-154; M-FGF-b; Prostatic growth factor; prostatropin
Common Name FGF2
Biological Activity ED50 ≤ 1.0 ng/mL; determined by the dose-dependent proliferation of BALB/3T3 cells.
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Sequence Human FGF-basic, amino acids 10-155
Content And Storage 4°C
Endotoxin Level <0.1 ng/μg
Shipping Condition Wet Ice
Expression System E. coli
Protein Family Growth Factors & Receptors
Protein Form Recombinant, Ligand, Truncated
Form Lyophilized
Protein Subtype FGFs (Fibroblast Growth Factors)
Research Category Neurobiology, Oncology, Stem Cell Research, Microbiology, Differentiation, Angiogenesis
Product Line Gibco™
Purity or Quality Grade >95% by SDS-PAGE
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Certificates

Certificates

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5 results found
Lot Number Certificate Type Date Product Code
Lot Number2929626 Certificate TypeCertificate of Analysis Date07/06/2024 Product CodePHG0021
Lot Number2786198 Certificate TypeCertificate of Analysis Date27/10/2023 Product CodePHG0021
Lot Number2549637 Certificate TypeCertificate of Analysis Date26/08/2023 Product CodePHG0021
Lot Number2498431 Certificate TypeCertificate of Analysis Date03/02/2023 Product CodePHG0021
Lot Number476682H Certificate TypeCertificate of Analysis Date10/07/2020 Product CodePHG0021
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