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Gibco™ Human IFN-gamma Recombinant Protein Product Code.: 10474733
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Gibco™ Human IFN-gamma Recombinant Protein

Product Code. p-5232730
100 μg, Each
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Quantity:
1 mg
100 μg
Unit Size:
Each
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Product Code. 10474733

Brand: Gibco™ PHC4031

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Description

Recombinant Protein

Carrier-Free

IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor, and immune interferon that is produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin and other cytokines. IFN gamma is a dimeric protein consisting of two 146 amino acid subunits. IFN gamma is a glycoprotein that exists, functionally, as a homodimer of approximately 45 kDa. On SDS-PAGE, IFN gamma appears as a combination of 25, 20 and minor 15.5 kDa bands as a result of differential glycosylation. The biological activity of the IFN gamma homodimer is highly species specific. Human IFN gamma does not show cross-reactivity with mouse. IFN gamma function includes the following: antiviral activity, tumor antiproliferative activity, induction of class I and II MHC, macrophage activation, and enhanced immunoglobulin secretion by B lymphocytes. IFN gamma is involved in cytokine regulation and also acts synergistically with other cytokines. Activation of IFN gamma takes place through binding of IFN gamma receptor I and II, and activating the JAK-STAT pathway. IFN gamma does not show any homology with IFN alpha or IFN beta but human IFN gamma shows about 40% sequence homology with mouse IFN gamma. IFN gamma is upregulated by IL2, FGF basic, EGF and downregulated by vitamin D3 or DMN. IFN gamma gene mutations are associated with aplastic anemia.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P01579
For Use With (Application) Control, ELISA, Functional Assay, Immunohistochemistry, Western Blot
Formulation 40 mM tris with no preservative; pH 7.4
Gene ID (Entrez) 3458
Molecular Weight (g/mol) 16.9 kDa
Name Human IFN-gamma
Purification Method Sequential Chromatography
Quantity 100 μg
Endotoxin Concentration <0.1 ng/ μg
Gene Alias BoIFNG; cytokine; EGK_03901; gamma interferon; gamma interferon precursor; gamma-interferon; gamma-interferon precursor (AA -23 to 143); H-IFN-g; IFG; IFI; IFN gamma; IFN ?; Ifng; IFN-g; IFNG2; IFN-gamma; IFN-gamma precursor; IFN-y; IFN?; Immune interferon; Interferon; interferon gamma; interferon gamma precursor; interferon gamma type 2; Interferon y; Interferon ?; interferon, gamma; interferon-gama; interferon-gamma; Interferon-gamma level; interferon-gamma precursor; Interferon?; M-IFN-g; R-IFN-g
Common Name IFN gamma
Biological Activity ED50 = 0.5 - 3.0 ng/mL; determined by the dose-dependent cytostasis of human WiDr cells.
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Sequence QDPYVKEAEN LKKYFNAGHS DVADNGTLFL GILKNWKEES DRKIMQSQIV SFYFKLFKNF KDDQSIQKSV ETIKEDMNVK FFNSNKKKRD DFEKLTNYSV TDLNVQRKAI HELIQVMAEL SPAAKTGKRK RSQMLFQGRR ASQ
Content And Storage -80°C
Classification Carrier-Free
Endotoxin Level <0.1 ng/μg
Shipping Condition Dry Ice
Expression System E. coli
Protein Family Cytokines & Receptors
Protein Form Recombinant, Ligand
Form Liquid
Protein Subtype Interferons
Research Category Immunology, Signal Transduction, Stem Cell Research, Virology, Oncology
Product Line Gibco™
Purity or Quality Grade >95% by SDS-PAGE
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Lot Number2989076 Certificate TypeCertificate of Analysis Date16/10/2024 Product CodePHC4031
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