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Gibco™ Human M-CSF Recombinant Protein, PeproTech®

E. coli Recombinant Protein

606.00 DKK - 32410.00 DKK

Specifications

Accession Number P09603
For Use With (Application) ELISA, Functional Assay, Western Blot
Formulation protein with no preservative
Gene ID (Entrez) 1435
Molecular Weight (g/mol) 36.8
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Products 7
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
17862143
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Gibco™
300-25-100UG
100 μg
6450.00 DKK
100µg
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17882763
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Gibco™
300-25-10UG
10 μg
1470.00 DKK
10µg
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17882543
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Gibco™
300-25-1MG
1 mg
32410.00 DKK
1mg
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17832463
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Gibco™
300-25-250UG
250 μg
11360.00 DKK
250µg
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17882943
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Gibco™
300-25-2UG
2 μg
606.00 DKK
2µg
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17882053
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Gibco™
300-25-500UG
500 μg
19420.00 DKK
500µg
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17852253
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Gibco™
300-25-50UG
50 μg
3890.00 DKK
50µg
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Description

Description

M-CSF (Macrophage colony-stimulating factor, CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells. M-CSF also induces VEGF (vascular endothelial growth factor) secretion by macrophages, thereby mediating mobilization of endothelial progenitor cells and neovascularization. M-CSF is present as several bioactive isoforms that differ in potency and stability. The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or further cleaved and modified in the secretory vesicle. Further, M-CSF is a disulfide-bonded homodimer which is processed into one of two isoforms, a glycoprotein or a proteoglycan that has been modified by the addition of chondroitin sulfate to each subunit. Binding of M-CSF to its receptor, c-Fms (CSF-1R or CD115) induces dimerization of the receptor followed by internalization and degradation of the complex. Functionally, M-CSF is known to stimulate differentiation of hematopoietic stem cells to monocyte-macrophage cell populations in culture. M-CSF acts through the CSF receptor 1. Although human M-CSF shows activity on mouse cells, mouse CSF shows no activity on human cells.
Specifications
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