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Invitrogen™ Human Nectin-2 (CD112) Fc Chimera Recombinant Protein
Recombinant Protein
Brand: Invitrogen™ RP87967
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Description
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Specifications
| Q92692 | |
| Lyophilized | |
| 5819 | |
| NECTIN2 | |
| 1 mg | |
| RUO | |
| AI325026; AI987993; CD112; herpes virus entry mediator B; Herpesvirus entry mediator B; herpesvirus entry protein B; hveB; mHveB; MPH; Murine herpes virus entry protein B; murine herpesvirus entry protein B; nectin cell adhesion molecule 2; Nectin2; Nectin-2; Poliovirus receptor homolog; poliovirus receptor related 2; poliovirus receptor-like 2; poliovirus receptor-related 2; poliovirus receptor-related 2 (herpesvirus entry mediator B); poliovirus receptor-related protein 2; poliovirus sensitivity; PRR2; Pvr; Pvrl2; PVRR2; Pvs | |
| Protein | |
| Unconjugated | |
| Human CD112, amino acids Met1-Leu360 (Accession # NP_002847.1) with a C-terminal human IgG1 Fc region | |
| HEK293 cells |
| ELISA | |
| 50 mM tris with <0.1 μg/mL BSA, 0.01% mannitol, 0.01% Tween 80, 100 mM glycine, 10 mM NaCl, 5-8% trehalose and no preservative; pH 7.5 | |
| 70-80 kDa | |
| SDS-PAGE | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| <1.0 EU/ μg | |
| NECTIN2 | |
| Human | |
| Recombinant | |
| 1. Measured by its binding ability in a functional ELISA. Immobilized human CD226 at 2 μg/ml (100 μL/well) can bind human CD112 with a linear range of 6.4-800 ng/mL 2. Immobilized PVRIG Protein, Cynomolgus, Rhesus, Recombinant (His Tag) (at 2 μg/ml (100 μL/well) can bind Nectin-2 Protein, Human, Recombinant (hFc Tag), the EC50 of Nectin-2 Protein, Human, Recombinant (hFc Tag)is 0.2-1.2 ng/mL) | |
| >95% as determined by SDS-PAGE. |