Transporter proteins play a key role in pharmacology, affecting how drugs are moved across cellular membranes. The Silencer™ Select Human Drug Transporter siRNA Library provides investigators with a focused RNAi screening platform targeting the most up-to-date transporter genes important in entry and extrusion of drugs into and out of cells. Target genes include those impacting absorption, distribution, metabolism and excretion of many drugs. The Silencer Select Human Drug Transporter siRNA Library contains 297 Ambion™ Silencer Select highly potent and chemically-modified siRNAs targeting 99 drug transporter genes. This library was designed using the most up-to-date genome databases, including the NCBI RefSeq database and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC). The Silencer Select siRNAs are designed using Thermo Fisher Scientific's leading algorithms—along with our novel locked nucleic acid (LNA) chemical modifications, this helps to maximize the efficacy, specificity and potency to RNAi screens against drug transporter genes.
Superior efficacy—Reduce off target effects by up to 90% due to latest design algorithms and LNA chemical modifications
Highest efficiency—Perform knockdown studies with 100-fold more potent siRNAs than currently available siRNAs
Dependable—Achieve faster discoveries via consistency of gene knockdown and reliability of phenotypic results
Convenient—Reduce data de-convolution and accelerate target validation with our arrayed format
Customizable—Choose the best option for your workflow demands, including additional siRNA scales and pooled formats
Why use the Silencer Select Human Drug Transporter siRNA Library?
Together with careful bioinformatics selection of gene targets, Silencer Select siRNAs are optimized with latest design algorithms, proprietary chemical modifications and high quality synthesis to help ensure desired RNAi outcomes. The Silencer Select Human Drug Transporter siRNA Library contains our pre-designed and when available, validated siRNAs generated with highest potency and specificity in mind so you can focus on the highest data quality backed by the best in industry guarantee.
Silencer Select siRNA libraries empower you with highly potent siRNAs to maximize discovery with even less
Ambion Silencer Select siRNAs are designed with the highest potency of available siRNAs, resulting in 100-fold more potent siRNAs and allowing gene knockdowns at the lowest concentrations (see figure below). The highly potent Silencer Select siRNAs allow you to use even lower concentrations of siRNAs, which helps to minimize off target effects, reduce false negative data and maximize siRNA library output for additional screens and data validation. The Silencer Select Human Drug Transporter siRNA Library contains 0.25 nmol of each highly potent siRNA, sufficient for at least 500 transfections (at 5 nM siRNA, 100 μL transfection volume).
Flexibility to meet your workflow needs
Thermo Fisher Scientific offers a comprehensive list of pre-defined or custom siRNA libraries to human, mouse or rat genes with 1, 2, or 5 nmol of each siRNA or larger sizes. For a complete gene list, additional information or to discuss your research with one of our technical experts, contact your local sales representative or e-mail us at RNAilibraries@lifetech.com.
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