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  6. ISO 1, Tocris Bioscience™

ISO 1, Tocris Bioscience™

Product Code. 30002036
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Macrophage migration inhibitory factor (MIF) inhibitor

ISO 1 is a macrophage migration inhibitory factor (MIF) inhibitor (IC50 = 7 μM); inhibits MIF tautomerase activity in vitro and in vivo. Protective against mouse models of streptozotocin -induced diabetes mellitus; blocks anti-inflammatory response following LPS exposure and increases survival. Inhibits airway remodeling in a mouse model of chronic asthma. Cell permeable; orally bioavailable.

Chemical Identifiers

CAS 478336-92-4
Molecular Formula C12H13NO4
Molecular Weight (g/mol) 235.239
InChI Key CLVQGFPQFNASJH-UHFFFAOYSA-N
Synonym iso-1, mif antagonist, iso-1, methyl 2-3-4-hydroxyphenyl-4,5-dihydroisoxazol-5-yl acetate, 5-isoxazoleacetic acid, 4,5-dihydro-3-4-hydroxyphenyl-, methyl ester, macrophage migration inhibitory factor antagonist, iso-1, s,r-3-4-hydroxyphenyl-4,5-dihydro-5-isoxazole acetic acid, methyl ester, methyl 2-3-4-oxocyclohexa-2,5-dien-1-ylidene-1,2-oxazolidin-5-yl acetate, 3-4-hydroxyphenyl-2-isoxazoline-5-acetic acid methyl ester, methyl2-3-4-hydroxyphenyl-4,5-dihydroisoxazol-5-yl acetate, 3-4-hydroxyphenyl-4,5-dihydro-5-isoxazoleacetic methyl ester
PubChem CID 6098948
IUPAC Name methyl 2-[3-(4-oxocyclohexa-2,5-dien-1-ylidene)-1,2-oxazolidin-5-yl]acetate
SMILES COC(=O)CC1CC(=C2C=CC(=O)C=C2)NO1

Specifications

Color White
Quantity 10 mg
Formula Weight 235.24
Percent Purity >98%
Physical Form Solid
Chemical Name or Material ISO 1
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