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  7. JNJ 10191584 maleate, Tocris Bioscience™

JNJ 10191584 maleate, Tocris Bioscience™

Product Code. 18044202
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Quantity:
10 mg
50 mg
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Description

Selective H4 receptor antagonist; orally active

Highly selective histamine H4 receptor silent antagonist; binds with high affinity to the human H4 receptor (Ki = 26 nM). > 540-fold selective over the H3 receptor (Ki = 14.1 μM). Inhibits mast cell and eosinophil chemotaxis in vitro with IC50 values of 138 and 530 nM respectively. Orally active in vivo.

Chemical Identifiers

CAS 869497-75-6
Molecular Formula C17H21ClN4O5
Molecular Weight (g/mol) 396.83
MDL Number MFCD09878266
InChI Key BODOIXYJOORQBQ-UHFFFAOYSA-N
Synonym jnj 10191584 maleate
PubChem CID 77519402
IUPAC Name 6-chloro-2-(4-methylpiperazine-1-carbonyl)-1H-1,3-benzodiazole; formic acid; prop-2-enoic acid
SMILES OC=O.OC(=O)C=C.CN1CCN(CC1)C(=O)C1=NC2=CC=C(Cl)C=C2N1

Specifications

Quantity 10 mg
Formula Weight 394.81
Percent Purity >99%
Chemical Name or Material JNJ 10191584 maleate
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