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  7. JNJ 16259685, Tocris Bioscience™

JNJ 16259685, Tocris Bioscience™

Product Code. 18074292
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10 mg
50 mg
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Description

Highly potent, mGlu1-selective non-competitive antagonist

Sub-nanomolar potent, non-competitive mGlu1 antagonist (Ki = 0.34 nM). Inhibits glutamate-induced Ca2+ response at the human mGlu1 receptor with an IC50 value of 0.55 nM. Selective over mGlu5 (> 400-fold) and displays no activity at mGlu2, mGlu3, mGlu4, mGlu6, AMPA or NMDA receptors (IC50 > 10 μM). Centrally active following systemic administration.

Chemical Identifiers

CAS 409345-29-5
Molecular Formula C20H23NO3
Molecular Weight (g/mol) 325.408
InChI Key QOTAQTRFJWLFCR-UHFFFAOYSA-N
Synonym 3,4-dihydro-2h-pyrano 2,3-b quinolin-7-yl-cis-4-methoxycyclohexyl-methanone, 3,4-dihydro-2h-pyrano 2,3-b quinolin-7-yl-4-methoxycyclohexyl methanone, 7-4-methoxycyclohexanecarbonyl-2h,3h,4h-pyrano 2,3-b quinoline, 3,4-dihydro-2h-1-oxa-9-aza-anthracen-6-yl-4-methoxy-cyclohexyl-methanone, 3,4-dihydro-2h-pyrano 2,3-b quinolin-7-yl-cis-4-methoxycyclohexyl methanone, 7-1s,4s-4-methoxycyclohexanecarbonyl-2h,3h,4h-pyrano 2,3-b quinoline
PubChem CID 11313361
IUPAC Name 3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl-(4-methoxycyclohexyl)methanone
SMILES COC1CCC(CC1)C(=O)C2=CC3=CC4=C(N=C3C=C2)OCCC4

Specifications

Quantity 10 mg
Formula Weight 325.41
Percent Purity >98%
Chemical Name or Material JNJ 16259685
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