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NCL 00017509, Tocris Bioscience™

Product Code. 30000926
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Quantity:
1 mg
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Description

Potent and reversible NIMA related kinase 2 (Nek2) inhibitor

NCL 00017509 is a potent and reversible NIMA related kinase 2 (Nek2) inhibitor (IC50 = 56 nM). Induces increased mitotic abnormalities and mitotic delay. Cell permeable and active in vivo. In mice bearing pancreatic tumors, NCL 00017509 decreases PD-L1 expression and induces an anticancer immune response.

Specifications

CAS 1507367-00-1
Molecular Formula C15H12N6O
Linear Formula C15H12N6O
Quantity 1 mg
Synonym 3-6-ethynyl-9h-purin-2-yl amino benzeneacetamide
Solubility Information Soluble to 100mM in DMSO
InChI Key CJQGLUJHMXCLQY-UHFFFAOYSA-N
SMILES C#CC1=C2C(=NC(=N1)NC3=CC=CC(=C3)CC(=O)N)N=CN2
IUPAC Name 2-[3-[(6-ethynyl-7H-purin-2-yl)amino]phenyl]acetamide
Molecular Weight (g/mol) 292.302
PubChem CID 56944360
Formula Weight 292.3
Physical Form Solid
Chemical Name or Material 3-[(6-Ethynyl-9H-purin-2-yl)amino]benzeneacetamide
Grade >97%
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