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CellSensor™ CellSensor™ NFκB-bla THP-1 Cell Line
CellSensor™ NFκB-bla THP-1 Cell Line contains a beta-lactamase reporter gene under the control of the Nuclear Factor kappa B response element.
Brand: CellSensor™ K1662
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Description
- The CellSensor™ NFκB-bla THP-1 cell line contains a beta-lactamase reporter gene under the control of the Nuclear Factor kappa B (NFκB) response element stably integrated into THP-1 cells.
- To obtain the cell line, the NFκB-bla construct was transduced into THP-1 cells by lentivirus.
- Subsequent flow cytometry was used to isolate cells responsive to Tumor Necrosis Factor alpha (TNFα).
- The cell line was validated for DMSO tolerance, cell number, stimulation time, substrate loading time, and EC50 concentration of TNFα.
- The CellSensor™ NFκB-bla THP-1 cell line is responsive to TNFα and can be used to probe NFκB signaling pathways, including those involved in apoptosis, viral defense, cancer, inflammation, and autoimmune disease.
- This cell line can be adapted for high-throughput screening for agonists or antagonists with compound libraries.
- Candidate drugs can be tested for dose response against this cell line.
Specifications
| Cell-based beta lactamase reporter gene | |
| CellSensor™ Cell Lines are shipped on dry ice. Store in liquid nitrogen immediately upon receipt, or thaw for immediate use. | |
| 1 vial | |
| Cell Line | |
| CellSensor™ |
| Dividing Cells | |
| CellSensor™ | |
| TNF alpha, NIK, TLR, I kappa B, IRAK, IKK, NF-kappa B pathway | |
| THP-1 | |
| Signaling Pathway |
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Product Title
For Research Use Only. Not for use in diagnostic procedures.
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