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  8. 15125624

Thermo Scientific™ pH Gradient Buffers

Robust reproducible gradients that are applicable to a wide range of MAbs and ready to use with existing LC columns and systems, without the need to formulate mobile phases.

Brand:  Thermo Scientific™ 083273

1256.20 DKK valid until 2025-05-31
Use promo code "24127" to get your promotional price.

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Product Code. 15125624

  • 1322.32 DKK / 125mL

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Description

Description

Obtain fast and highly robust, reproducible HPLC gradients using Thermo Scientific™ CX-1 pH Gradient Buffers. Simple to optimize and easily automated, these buffers are applicable for HPLC separation of the majority of monoclonal antibody (mAb) biotherapeutics drugs. CX-1 pH Gradient Buffers are ready to use with existing HPLC columns without the need to formulate mobile phases. The CX-1 buffers save time in method development, facilitate method transfer to QA/QC for a wide range of mAb charge variants through a generic HPLC-based approach to mAb characterization, and do not require time-consuming mobile phase adjustments.

pH buffer solutions can be used to generate highly reproducible, linear pH gradients in cation exchange chromatography.

  • Robust, reproducible gradients
  • Predict biomolecule pH
  • Simple method optimization
  • Easily automated
  • Applicable to the majority of MAbs

Unlike traditional cation exchange chromatography using salt gradients, it is possible to predict the pH and the expected retention of the charge variants and use a narrow pH range to get a higher resolution separation.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

CX-1 pH Gradient Buffer A
Thermo Scientific
125 mL
125 mL
LC Columns and Systems
CX-1 pH Gradient Buffer A
5.6
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Videos
SDS
Documents

Documents

Scientific Resources

Application Notes

Application Note: Using the NISTmAb Reference Standard to Demonstrate a Simple Approach to Charge Variant Analysis File size: 958.5 kB
Application Note: Development of Ultra-fast pH-Gradient Ion Exchange Chromatography for the Separation of Monoclonal Antibody Charge Variants File size: 987.2 kB
Application Note: The Advantage of pH Gradient Buffers is Demonstrated by the Ion Exchange Separation of Charge Variants of Denosumab File size: 920.3 kB
Application Note: High-Resolution Charge Variant Analysis for Top-Selling Monoclonal Antibody Therapeutics Using a Linear pH Gradient Separation Platform File size: 1.3 MB
Application Note: High-Resolution Separation of Intact Monoclonal Antibody Isoforms File size: 349.6 kB
Application Note: A Fast and Robust Linear pH Gradient Separation Platform for Monoclonal Antibody (mAb) Charge Variant Analysis File size: 853 kB

Flyers

Flyer: Take Charge of Variant Analysis and see your Protein Separations in High Resolution File size: 704.1 kB
Flyer: The Right Columns and Consumables to Maximize your Pharmaceutical Workflow Version: 0419S File size: 327 kB

Catalogs

2019/2021 Chromatography Consumables Catalog - BioLC File size: 11.2 MB

Posters

Poster: ProPac Evolution | 20 Years of Charge Variant Innovation File size: 2.3 MB

Technical Notes

Technical Note: Development of Ultra-fast pH-Gradient Ion Exchange Chromatography for the Separation of Monoclonal Antibody Charge Variants File size: 987.2 kB

Product Information

Manuals

CX-1 pH Gradient Buffer User Manual Revision 05 Version: OCT.2018 File size: 4.7 MB
CX-1 pH Gradient Buffer QuickStart Version: FEB.2016 File size: 166.6 kB

Specification Sheets

Specification Sheet: CX-1 pH Gradient Buffers – Simple Method Development for Charge Variant Characterization File size: 992.6 kB
Certificates
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