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PRAS40 Monoclonal Antibody (73P21), Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen AHO1031
This item is not returnable.
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Description
The Akt signaling pathway contributes to the regulation of apoptosis after a variety of cell death signals. AKT1S1, also known as PRAS40, is a proline-rich substrate of the kinase AKT1 and is thought to play a role in neuroprotection mediated by nerve growth factor (NGF) after transient focal cerebral ischemia. AKT1S1 is also a substrate and potential regulator of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy. Treatment with the insulin-like growth factor-1 (IGF1) can induce the phosphorylation of AKT1S1 via the PI3K/AKT signaling pathway in PC12 cells.
Specifications
| PRAS40 | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 1% BSA and 0.1% sodium azide | |
| Q96B36 | |
| AKT1S1 | |
| Recombinant full length human PRAS40 expressed in E. coli. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 κ |
| Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
| 73P21 | |
| Unconjugated | |
| AKT1S1 | |
| 1110012J22Rik; 40 kDa proline-rich AKT substrate; AI227026; AKT1 substrate 1; AKT1 substrate 1 (proline rich); AKT1 substrate 1 (proline-rich); akt1s1; Lobe; Lobel; OTTHUMP00000196756; OTTHUMP00000196760; PKB/Akt substrate 40; Pras; PRAS40; Proline-rich AKT substrate; proline-rich AKT1 substrate 1 | |
| Mouse | |
| purified | |
| RUO | |
| 84335 | |
| -20°C | |
| Liquid |