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PX 12, Tocris Bioscience™

Product Code. 18044942
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Quantity:
10 mg
50 mg
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Description

Thioredoxin-1 inhibitor

Thioredoxin-1 (Trx-1) inhibitor; irreversibly inactivates Trx-1 as a substrate for reduction by thioredoxin reductase (TR); competitively inhibits the reduction of Trx-1 by TR (Ki = 30.8 μM). Attenuates expression of HIF-1α, VEGF and iNOS (IC50 values are 7.2, 10.4 and 18.1 μM respectively). Exhibits antitumor activity; directly inhibits tubulin in vitro and decreases tumor microvessel density in vivo.

Chemical Identifiers

CAS 141400-58-0
Molecular Formula C7H12N2S2
Molecular Weight (g/mol) 188.31
MDL Number MFCD18086851
InChI Key BPBPYQWMFCTCNG-UHFFFAOYNA-N
Synonym 2-sec-butyldisulfanyl-1h-imidazole, 2-1-methylpropyl dithio-1h-imidazole, 2-butan-2-yldisulfanyl-1h-imidazole, 1h-imidazole,2-1-methylpropyl dithio, 1h-imidazole, 2-1-methylpropyl dithio, iv 2 compound, iv-2 compound, 1-methylpropyl-2-imidazolyl disulfide
PubChem CID 219104
IUPAC Name 2-(butan-2-yldisulfanyl)-1H-imidazole
SMILES CCC(C)SSC1=NC=CN1

Specifications

Quantity 50 mg
Formula Weight 188.31
Percent Purity >99%
Chemical Name or Material PX 12
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