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Retinoic Acid, All Trans Isomer, MP Biomedicals™ Product Code.: 11431771
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Retinoic Acid, All Trans Isomer, MP Biomedicals™

Product Code. 11431771 Shop All MP Biomedical Products
50 mg
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Quantity:
50 mg
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Regulatory: This product fall under regulation “Lov om kemiske stoffer og produkter - lovbekendtgørelse nr. 1755 af 22. december 2006. If applicable, customers must provide a license before delivery.

Product Code. 11431771

Brand: MP Biomedicals 02190269.6

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This item is not returnable. View return policy
Regulatory: This product fall under regulation “Lov om kemiske stoffer og produkter - lovbekendtgørelse nr. 1755 af 22. december 2006. If applicable, customers must provide a license before delivery.

Description

Mediates the functions of vitamin A required for growth and development. Retinoic Acid, All Trans Isomer, MP Biomedicals has been used in various differentiation protocols, including B-cells, T cells and neurons, and is applied clinically to treat cancer

Retinoic acid (RA) is a vitamin A-derived, non-peptidic, small lipophilic molecule. It affects gene transcription and modulates a wide variety of biological processes, including cell proliferation and differentiation, including apoptosis.

  • Retinoic Acid mediated gene transcription depends on the rate of transport of Retinoic Acid to target cells and the timing of exposure of Retinoic Acid to RARs (Retinoic Acid Receptors) in the target tissues.
  • All-trans-Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR).
  • The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells.
  • Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA.
  • Retinoic acid primes embryonic stem cells to become neurons.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 302-79-4
Molecular Formula C20H28O2
Molecular Weight (g/mol) 300.44
MDL Number MFCD00001551
InChI Key SHGAZHPCJJPHSC-YCNIQYBTSA-N
Synonym retinoic acid, tretinoin, vitamin a acid, all-trans-retinoic acid, trans-retinoic acid, renova, airol, retin-a, vesanoid, atra
PubChem CID 444795
ChEBI CHEBI:15367
SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O

Specifications

Melting Point 173°C to 183°C
Quantity 50 mg
Solubility Information Soluble in methanol, chloroform (40mg/mL) or acetone (30mg/mL), slightly soluble in ethanol.
IUPAC Name (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
Formula Weight 300.4
Physical Form Powder

Safety and Handling

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Product Identifier
  • Retinoic Acid, All Trans Isomer
 Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 1
  • Skin corrosion/irritation Category 2
 Hazard Statement
  • H300-Fatal if swallowed.
  • H315-Causes skin irritation.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
  • P321-Specific treatment (see on this label).
  • P332+P313-If skin irritation occurs: Get medical advice/attention.
  • P405-Store locked up.
  • P501-Dispose of contents/container to in accordance with local/regional/national/international regulations..
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