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Thermo Scientific Chemicals SP600125, 98%, Thermo Scientific Chemicals Product Code.: 15498689
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Thermo Scientific Chemicals SP600125, 98%, Thermo Scientific Chemicals

Product Code. 15498689
50 mg
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50 mg
100 mg
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Product Code. 15498689

Brand: Thermo Scientific Chemicals J67272.MF

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Description

SP 600125 is a potent and reversible inhibitor of JNK1-3 with an IC50 value of 0.11 M.1 It is cell-permeable and dose-dependently inhibits c-Jun phosphorylation in cells, blocking the expression of COX-2 and TNF-α in monocytes and IL-10, TNF-α, and IFN-γ in T-cells. SP 600125 also prevents apoptosis in many cell types, including B-cells, and inhibits autophagy in HeLa cells. Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC50 > 10 ?M). Shown to have reduced selectivity over other protein kinases under certain conditions. Prevents BMP9-induced osteogenic differentiation of MSCs.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 129-56-6
Molecular Formula C14H8N2O
Synonym 1,9-Pyrazoloanthrone;

Specifications

Quantity 50 mg
Description Yellow to brown
Content And Storage -30°C to -10°C
Formula Weight 220.23
Solubility Soluble in DMSO at approx. 20mg/ml
Product Type SP600125, 99%
Form Solid
InChI Key ACPOUJIDANTYHO-UHFFFAOYSA-N
SMILES O=C1C2=C3C(NN=C3C3=CC=CC=C13)=CC=C2
IUPAC Name 14,15-diazatetracyclo[7.6.1.0²,⁷.0¹³,¹⁶]hexadeca-1(15),2,4,6,9(16),10,12-heptaen-8-one
Molecular Weight (g/mol) 220.23
Assay 99%
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5 results found
Lot Number Certificate Type Date Catalog Number
Lot NumberP06L012 Certificate TypeCertificate of Analysis Date10/03/2025 Catalog NumberJ67272.MF,J67272.MC
Lot NumberZ20K061 Certificate TypeCertificate of Analysis Date26/12/2024 Catalog NumberJ67272.MF,J67272.MC
Lot NumberW10K016 Certificate TypeCertificate of Analysis Date19/11/2024 Catalog NumberJ67272.MF,J67272.MC
Lot NumberZ28J015 Certificate TypeCertificate of Analysis Date11/06/2024 Catalog NumberJ67272.MF,J67272.MC
Lot NumberZ28J013 Certificate TypeCertificate of Analysis Date09/01/2024 Catalog NumberJ67272.MF,J67272.MC

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