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  6. TC-I 15, Tocris Bioscience™

TC-I 15, Tocris Bioscience™

Product Code. 30001641
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Quantity:
10 mg
50 mg
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Description

Potent α2β1 inhibitor; displays antithrombotic activity in vivo

TC-I 15 is a potent α2β1 integrin inhibitor (IC50 values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). TC-I 15 displays selectivity for α2β1 over αvβ3, α5β1, α6β1 and αIIbβ3 at concentrations exceeding 1000 nM. TC-I 15 reduces collagen IV production in mesangial cells. Active in vivo; TC-I 15 prevents ferric chloride-induced clot formation in mice.

Chemical Identifiers

CAS 916734-43-5
Molecular Formula C23H28N4O6S2
Molecular Weight (g/mol) 520.619
InChI Key XKLHCUGVLCGKKX-RBUKOAKNSA-N
Synonym tc-i 15, n-4r-5,5-dimethyl-3-phenylsulfonyl-4-thiazolidinyl carbonyl-3-phenylmethyl amino carbonyl amino-l-alanine
PubChem CID 90488948
IUPAC Name (2S)-2-[[(4R)-3-(benzenesulfonyl)-5,5-dimethyl-1,3-thiazolidine-4-carbonyl]amino]-3-(benzylcarbamoylamino)propanoic acid
SMILES CC1(C(N(CS1)S(=O)(=O)C2=CC=CC=C2)C(=O)NC(CNC(=O)NCC3=CC=CC=C3)C(=O)O)C

Specifications

Quantity 50 mg
Formula Weight 520.62
Percent Purity >98%
Chemical Name or Material TC-I 15
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