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Tocris Bioscience™ TM2 TEAD inhibitor

Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling

Brand:  Tocris Bioscience™ 7917/10

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Product Code. 18706075

  • 1170.00 DKK / 10mg

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Description

Description

TM2 TEAD inhibitor is a potent and reversible TEA domain transcription factor inhibitor (IC50 = 38 nM and 156 nM for TEAD4 auto-palmitoylation and TEAD2 palmitoylation, respectively). It inhibits TEAD-YAP association and transcriptional activity. TM2 TEAD inhibitor exhibits strong antiproliferation effects as a single agent or in combination with a MEK inhibitor in YAP-dependent cancer cells. Also inhibits YAP-dependent liver organoid growth ex vivo.
Specifications

Specifications

4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide
10 mg
C26H33N3O3
1008768-41-9
YAP1
0.98
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