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Tocris Bioscience™ VH 298
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Artikelnummer. 18770268
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10 mg
50 mg
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18770268 50 mg
18721378 10 mg
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Artikelnummer. 18770268 Leverandør Tocris Bioscience™ Leverandørnr. 6156/50

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Descrizione

High-affinity inhibitor of VHL

VH 298 is a high-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). Blocks interaction between VHL and HIF-α downstream of HIF-α hydroxylation, initiating hypoxic response. Results in time- and concentration-dependent accumulation of hydroxylated HIF-α, and upregulates mRNA and protein levels of HIF target genes, with similar transcriptional profile to hypoxia. Cell permeable.

Negative control cis VH 298 also available.

TRUSTED_SUSTAINABILITY

Specifica

Mængde 50 mg
Mål Ubiquitin Ligase (E3)
Molekylær formel C27H33N5O4S
Formel vægt 523.65g/mol
Produkttype Inhibitor

For Research Use Only

Titolo del prodotto
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