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  8. YM 58483, Tocris Bioscience™

YM 58483, Tocris Bioscience™

Product Code. 18065932
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Quantity:
10 mg
50 mg
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Description

Inhibitor of SOCE in non-excitable cells

YM 58483 is a blocker of store-operated Ca2+ entry (SOCE), which mediates the activation of non-excitable cells (e.g. lymphocytes). Inhibits calcium release-activated calcium (CRAC) channels; suppresses thapsigargin -induced sustained Ca2+ influx (IC50 = 100 nM). Displays immuno-modulatory and anti-inflammatory effects; suppresses cytokine production and proliferation of T cells in vitro.

Chemical Identifiers

CAS 223499-30-7
Molecular Formula C15H9F6N5OS
Molecular Weight (g/mol) 421.321
InChI Key XPRZIORDEVHURQ-UHFFFAOYSA-N
Synonym btp2, crac channel inhibitor, btp2, n-4-3,5-bis trifluoromethyl pyrazol-1-yl phenyl-4-methylthiadiazole-5-carboxamide, n-4-3,5-bis trifluoromethyl-1h-pyrazol-1-yl phenyl-4-methyl-1,2,3-thiadiazole-5-carboxamide, maybridge3_006679, d0jv2p, btp-2, ym hplc, 4-methyl-4'-3,5-bis trifluoromethyl-1h-pyrazol-1-yl-1,2,3-thiadiazole-5-carboxanilide, 1,2,3-thiadiazole-5-carboxamide,n-4-3,5-bis trifluoromethyl-1h-pyrazol-1-yl phenyl-4-methyl
PubChem CID 2455
IUPAC Name N-[4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide
SMILES CC1=C(SN=N1)C(=O)NC2=CC=C(C=C2)N3C(=CC(=N3)C(F)(F)F)C(F)(F)F

Specifications

Quantity 50 mg
Formula Weight 421.32
Percent Purity >99%
Chemical Name or Material YM 58483
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