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Entacapone, MedChemExpress
MedChemExpress Entacapone is a potent, reversible, peripherally acting and orally active catechol-O-methyltransferase (COMT) inhibitor.
Brand: Medchem Express HY-14280
This item is not returnable.
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Description
Entacapone inhibits COMT from rat brain, erythrocytes and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M (PST-M) and PST-P (IC50s>50 μM). Entacapone can be used for the research of Parkinson's disease. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders.Specifications
| Entacapone | |
| Yellow | |
| C14H15N3O5 | |
| DMSO : 33.33 mg/mL (109.17 mM; Need ultrasonic) ∣H2O : 2 mg/mL (6.55 mM; ultrasonic and adjust pH to 10 with NaOH) | |
| 305.29 | |
| 98.79% | |
| Powder |
| 130929-57-6 | |
| Research | |
| 10 mg | |
| O=C(N(CC)CC)/C(C#N)=C/C1=CC([N+]([O-])=O)=C(O)C(O)=C1 | |
| 305.29 | |
| Research | |
| Neuroscience-Neurodegeneration |
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Product Title
Entacapone, MedChemExpress
Research purposes only
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